Observe Carefully (3)pentobarbital will reduce the extent or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Sturdy or average CYP3A4 inducers may enhance charge of diazepam elimination; thus, efficacy of diazepam may very well be reduced.pentobarbital will reduce the level or result of omb